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One Fire, Many Flames: The Immune Response Fueling Allergies, Asthma, and Eczema

May 14, 2026 | AAFA National
Asthma. Seasonal allergies. Food allergies. Eczema. Nasal polyps. Eosinophilic esophagitis. What if these aren’t separate problems – but different expressions of the same one?

We’re pulling back the curtain on a common thread linking many of these conditions — an overactive immune response called type 2 inflammation. Think of it as a fire burning inside the body. Depending on where it flares, it might show up as itchy skin, a wheezing chest, a constantly runny nose, or a reaction to certain foods.

This immune response leads to a community of diseases and understanding how it works is changing everything about how these diseases are treated.

We discuss why so many people have more than one of these conditions, and how treatments are now targeting the root cause — not just the symptoms.

In this episode:

  • How the immune system’s “alarm system” gets stuck in the “on” position
  • Why allergic conditions so often occur together
  • How some treatments target, block, or change the immune system’s response
  • Making the most of your allergy appointment – what information to share and how to ask better questions at your next doctor’s visit

(0:00) Introduction
(0:32) Understanding Allergies and Immune Response
(2:14) Types of Allergic Conditions and Their Connections
(4:11) Advancements in Allergy Treatments
(5:38) When to Consult an Allergist
(6:57) Preparing for Your Allergist Appointment
(8:38) Personalized Treatment Approaches

Resources:

Dave Stukus, MD, is a board-certified allergist/immunologist and a member of AAFA’s Medical Scientific Council.

Disclosure:
This episode was produced by the Asthma and Allergy Foundation of America and made possible in part by support from Sanofi and Regeneron. Its contents are solely the responsibility of AAFA and the guest speakers, and do not necessarily represent the official views of the sponsors.